• Full Name: Bader Lab Genes Version: February-2014

    Genes

    Total: 300
    In Groups: 298

    Full Citation

    Too many roads not taken: Aled M. Edwards, Ruth Isserlin, Gary D. Bader, Stephen V. Frye, Timothy M. Willson & Frank H. Yu Nature 470, 163–165 (10 February 2011) doi:10.1038/470163a. PMID: 21307913

    • Full Name: Caris Molecular Intelligence Version: 04-September-2020

    Genes

    Total: 608
    In Groups: 607

    Full Citation

    http://www.carismolecularintelligence.com/

    License

    Unknown

    • Full Name: dGENE - The Druggable Gene List Version: 27-Jun-2013

    Genes

    Total: 2257
    In Groups: 2250

    Full Citation

    Prioritizing Potentially Druggable Mutations with dGene: An Annotation Tool for Cancer Genome Sequencing Data. Kumar RD, Chang LW, Ellis MJ, Bose R. PLoS One. 2013 Jun 27;8(6):e67980. PMID: 23826350

    • Full Name: Foundation One Version: 03-September-2020

    Genes

    Total: 664
    In Groups: 662

    Full Citation

    High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. Wagle N, Berger MF, ..., Meyerson M, Gabriel SB, Garraway LA. Cancer Discov. 2012 Jan;2(1):82-93. PMID: 22585170

  • GO

    • Full Name: The Gene Ontology Version: 05-September-2020

    Genes

    Total: 3667
    In Groups: 3588

    Full Citation

    Gene ontology: tool for the unification of biology. The unification of biology. The Gene Ontology Consortium. Ashburner M, Ball CA, ..., Rubin GM, Sherlock G. Nat Genet. 2000 May;25(1):25-9. PMID: 10802651

    • Full Name: Guide to Pharmacology Genes Version: 4-March-2015

    Genes

    Total: 1969
    In Groups: 1969

    Full Citation

    Pawson, Adam J., et al. "The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands." Nucleic acids research 42.D1 (2014): D1098-D1106. PMID: 24234439

    • Full Name: The druggable genome and support for target identification and validation in drug development (Hingorani & Casas, 2017) Version: 31-May-2017

    Genes

    Total: 4479
    In Groups: 4476

    Full Citation

    The druggable genome and support for target identification and validation in drug development. Finan C, Gaulton A, Kurger F, Lumbers T, Shah T, Engmann J, Galver L, Kelly R, Karlsson A, Santos R, Overington J, Hingorani A, Casas JP. Sci. Transl. Med. 2017 Mar 29;9(383):eaag1166 PMID: 28356508

    • Full Name: The druggable genome (Hopkins & Groom, 2002) Version: 11-September-2012

    Genes

    Total: 2676
    In Groups: 2671

    Full Citation

    The druggable genome. Hopkins AL, Groom CR. Nat Rev Drug Discov. 2002 Sep;1(9):727-30. PMID: 12209152

    • Full Name: The Human Protein Atlas Version: 19.3

    Genes

    Total: 1325
    In Groups: 1325

    Full Citation

    Uhlén M, Fagerberg L, Hallström BM, et al. Proteomics. Tissue-based map of the human proteome. Science. 2015;347(6220):1260419. doi:10.1126/science.1260419. PMID: 25613900

  • IDG

    • Full Name: Illuminating the Druggable Genome Version: 15-July-2019

    Genes

    Total: 329
    In Groups: 329

    Full Citation

    https://druggablegenome.net/

    • Full Name: Memorial Sloan Kettering IMPACT Version: May-2015

    Genes

    Total: 350
    In Groups: 350

    Full Citation

    Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology. Cheng, Donavan T., et al. The Journal of Molecular Diagnostics 17.3 (2015): 251-264. PMID: 25801821

    • Full Name: Oncomine Comprehensive Assay Version: v3

    Genes

    Total: 161
    In Groups: 161

    Full Citation

    "Oncomine Comprehensive Assay v3.", Thermo Fisher Scientific Inc. Accessed 8 Sep 2020. https://assets.thermofisher.com/TFS-Assets/LSG/brochures/oncomine-comprehensive-assay-v3-flyer.pdf

    • Full Name: Pharos Version: 03-September-2020

    Genes

    Total: 6052
    In Groups: 6050

    Full Citation

    Nguyen, D.-T., Mathias, S. et al, "Pharos: Collating Protein Information to Shed Light on the Druggable Genome", Nucl. Acids Res.i>, 2017, 45(D1), D995-D1002. DOI: 10.1093/nar/gkw1072. PMID: 27903890

    • Full Name: The druggable genome: an update (Russ & Lampel, 2005) Version: 26-July-2011

    Genes

    Total: 3361
    In Groups: 3093

    Full Citation

    The druggable genome: an update. Russ AP, Lampel S. Drug Discov Today. 2005 Dec;10(23-24):1607-10. PMID: 16376820

    • Full Name: Tempus xT Version: 11-November-2018

    Genes

    Total: 596
    In Groups: 595

    Full Citation

    Beaubier, N, Tell, R, Lau, D, Parsons, JR, Bush, S, Perera, J, Sorrells, S, Baker, T, Chang, A, Michuda, J, Iguartua, C, MacNeil, S, Shah, K, Ellis, P, Yeatts, K, Mahon, B, Taxter, T, Bontrager, M, Khan, A, Huether, R, Lefkofsky, E, & White, KP. Clinical validation of the tempus xT next-generation targeted oncology sequencing assay. Oncotarget 2019 Mar 22;10(24):2384-2396. PMID: 31040929

    • Full Name: The ChEMBL Bioactivity Database Version: ChEMBL_27

    Drugs

    Total: 12961
    In Groups: 12961

    Full Citation

    The ChEMBL bioactivity database: an update. Bento AP, Gaulton A, Hersey A, Bellis LJ, Chambers J, Davies M, Kruger FA, Light Y, Mak L, McGlinchey S, Nowotka M, Papadatos G, Santos R, Overington JP. Nucleic Acids Res. 42(Database issue):D1083-90. PubMed ID: 24214965

    • Full Name: Wikidata Version: 12-August-2020

    Drugs

    Total: 128
    In Groups: 128

    Full Citation

    Denny Vrandečić and Markus Krötzsch. 2014. Wikidata: a free collaborative knowledgebase. Commun. ACM 57, 10 (October 2014), 78–85. DOI:https://doi.org/10.1145/2629489

    • Full Name: Ensembl Version: 101_38

    Genes

    Total: 60671
    In Groups: 39943

    Full Citation

    Ensembl 2011. Flicek P, Amode MR, ..., Vogel J, Searle SM. Nucleic Acids Res. 2011 Jan;39(Database issue)800-6. Epub 2010 Nov 2. PMID: 21045057

    • Full Name: NCBI Entrez Gene Version: 14-September-2020

    Genes

    Total: 42767
    In Groups: 42767

    Full Citation

    Entrez Gene: gene-centered information at NCBI. Maglott D, Ostell J, Pruitt KD, Tatusova T. Nucleic Acids Res. 2011 Jan;39(Database issue)52-7. Epub 2010 Nov 28. PMID: 21115458

    • Full Name: Cancer Commons Version: 25-July-2013

    Genes

    Total: 48
    In Groups: 48

    Drugs

    Total: 80
    In Groups: 72

    Interactions

    Total: 109

    Full Citation

    Cancer Commons: Biomedicine in the Internet Age. Shrager J, Tenenbaum JM, and Travers M. Collaborative Computational Technologies for Biomedical Research, (Sean Elkins, Maggie Hupcey, and Antony Williams Eds). Wiley, 2010.

  • CGI

    • Full Name: Cancer Genome Interpreter Version: 14-September-2020

    Genes

    Total: 123
    In Groups: 122

    Drugs

    Total: 169
    In Groups: 123

    Interactions

    Total: 398

    Full Citation

    https://www.cancergenomeinterpreter.org/

    • Full Name: The ChEMBL Bioactivity Database Version: chembl_23

    Genes

    Total: 1085
    In Groups: 1084

    Drugs

    Total: 2716
    In Groups: 2681

    Interactions

    Total: 7610

    Full Citation

    The ChEMBL bioactivity database: an update. Bento AP, Gaulton A, Hersey A, Bellis LJ, Chambers J, Davies M, Kruger FA, Light Y, Mak L, McGlinchey S, Nowotka M, Papadatos G, Santos R, Overington JP. Nucleic Acids Res. 42(Database issue):D1083-90. PMID: 24214965

    • Full Name: CIViC: Clinical Interpretation of Variants in Cancer Version: 18-September-2020

    Genes

    Total: 143
    In Groups: 0

    Drugs

    Total: 275
    In Groups: 0

    Interactions

    Total: 642

    Full Citation

    Griffith M*, Spies NC*, Krysiak K*, McMichael JF, Coffman AC, Danos AM, Ainscough BJ, Ramirez CA, Rieke DT, Kujan L, Barnell EK, Wagner AH, Skidmore ZL, Wollam A, Liu CJ, Jones MR, Bilski RL, Lesurf R, Feng YY, Shah NM, Bonakdar M, Trani L, Matlock M, Ramu A, Campbell KM, Spies GC, Graubert AP, Gangavarapu K, Eldred JM, Larson DE, Walker JR, Good BM, Wu C, Su AI, Dienstmann R, Margolin AA, Tamborero D, Lopez-Bigas N, Jones SJ, Bose R, Spencer DH Wartman LD, Wilson RK, Mardis ER, Griffith OL†. 2016. CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer. Nat Genet. 49, 170–174 (2017); doi: doi.org/10.1038/ng.3774. PMID: 28138153

    • Full Name: Clearity Foundation Biomarkers Version: 26-July-2013

    Genes

    Total: 34
    In Groups: 34

    Drugs

    Total: 64
    In Groups: 51

    Interactions

    Total: 163

    Full Citation

    http://www.clearityfoundation.org/healthcare-pros/drugs-and-biomarkers.aspx

    • Full Name: Clearity Foundation Clinical Trial Version: 15-June-2013

    Genes

    Total: 108
    In Groups: 100

    Drugs

    Total: 115
    In Groups: 73

    Interactions

    Total: 281

    Full Citation

    https://www.clearityfoundation.org/form/findtrials.aspx

    • Full Name: Catalogue Of Somatic Mutations In Cancer Version: 4-Sep-2020

    Genes

    Total: 15
    In Groups: 15

    Drugs

    Total: 28
    In Groups: 25

    Interactions

    Total: 37

    Full Citation

    Forbes SA, Bhamra G, Bamford S, et al. The Catalogue of Somatic Mutations in Cancer (COSMIC). Curr Protoc Hum Genet. 2008;Chapter 10:Unit-10.11. doi:10.1002/0471142905.hg1011s57. PMID: 18428421

    • Full Name: Database of Curated Mutations Version: 27-September-2017

    Genes

    Total: 35
    In Groups: 35

    Drugs

    Total: 39
    In Groups: 37

    Interactions

    Total: 76

    Full Citation

    DoCM: a database of curated mutations in cancer. Ainscough BJ, Griffith M, Coffman AC, Wagner AH, Kunisaki J, Choudhary MN, McMichael JF, Fulton RS, Wilson RK, Griffith OL, Mardis ER. Nat Methods. 2016;13(10):806-7. PMID: 27684579

    • Full Name: DrugBank - Open Data Drug & Drug Target Database Version: 5.1.7

    Genes

    Total: 2911
    In Groups: 2837

    Drugs

    Total: 5801
    In Groups: 2609

    Interactions

    Total: 14441

    Full Citation

    DrugBank 4.0: shedding new light on drug metabolism. Law V, Knox C, Djoumbou Y, Jewison T, Guo AC, Liu Y, Maciejewski A, Arndt D, Wilson M, Neveu V, Tang A, Gabriel G, Ly C, Adamjee S, Dame ZT, Han B, Zhou Y, Wishart DS.Nucleic Acids Res. 2014 Jan 1;42(1):D1091-7. PMID: 24203711

  • DTC

    • Full Name: Drug Target Commons Version: 02-September-2020

    Genes

    Total: 1016
    In Groups: 1015

    Drugs

    Total: 6290
    In Groups: 6284

    Interactions

    Total: 23879

    Full Citation

    Drug Target Commons 2.0: a community platform for systematic analysis of drug–target interaction profiles. Tanoli Z, Alam Z, Vähä-Koskela M, Malyutina A, Jaiswal A, Tang J, Wennerberg K, Aittokallio T. Database. 2018. PMID: 30219839

  • FDA

    • Full Name: FDA Pharmacogenomic Biomarkers Version: 04-September-2020

    Genes

    Total: 89
    In Groups: 83

    Drugs

    Total: 291
    In Groups: 256

    Interactions

    Total: 427

    Full Citation

    https://www.fda.gov/drugs/science-and-research-drugs/table-pharmacogenomic-biomarkers-drug-labeling

    License

    Public Domain

    • Full Name: Guide to Pharmacology Interactions Version: 20-July-2020

    Genes

    Total: 1700
    In Groups: 1696

    Drugs

    Total: 7356
    In Groups: 2328

    Interactions

    Total: 14661

    Full Citation

    Pawson, Adam J., et al. "The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands." Nucleic acids research 42.D1 (2014): D1098-D1106. PMID: 24234439

    • Full Name: The Jackson Laboratory Clinical Knowledgebase Version: 15-September-2020

    Genes

    Total: 85
    In Groups: 85

    Drugs

    Total: 676
    In Groups: 349

    Interactions

    Total: 1671

    Full Citation

    Sara E. Patterson, Rangjiao Liu, Cara M. Statz, Daniel Durkin, Anuradha Lakshminarayana, and Susan M. Mockus. The Clinical Trial Landscape in Oncology and Connectivity of Somatic Mutational Profiles to Targeted Therapies. Human Genomics, 2016 Jan 16;10(1):4. PMID: 26772741

    • Full Name: My Cancer Genome Version: 20-Jun-2017

    Genes

    Total: 182
    In Groups: 181

    Drugs

    Total: 252
    In Groups: 227

    Interactions

    Total: 865

    Full Citation

    Abramson, R., Aston, J., C. Lovly. 2017. My Cancer Genome.

    • Full Name: MyCancerGenome Clinical Trial Version: 30-February-2014

    Genes

    Total: 83
    In Groups: 80

    Drugs

    Total: 112
    In Groups: 82

    Interactions

    Total: 377

    Full Citation

    http://www.mycancergenome.org/

  • NCI

    • Full Name: NCI Cancer Gene Index Version: 14-September-2017

    Genes

    Total: 1045
    In Groups: 1037

    Drugs

    Total: 1519
    In Groups: 711

    Interactions

    Total: 6231

    Full Citation

    https://wiki.nci.nih.gov/display/cageneindex

    License

    Public domain

    • Full Name: OncoKB: A Precision Oncology Knowledge Base Version: 23-July-2020

    Genes

    Total: 55
    In Groups: 54

    Drugs

    Total: 89
    In Groups: 80

    Interactions

    Total: 150

    Full Citation

    OncoKB: A Precision Oncology Knowledge Base. Chakravarty D, Gao J, Phillips S, et. al. JCO Precision Oncology 2017 :1, 1-16. PMID: 28890946

    • Full Name: PharmGKB - The Pharmacogenomics Knowledgebase Version: 18-August-2020

    Genes

    Total: 1274
    In Groups: 1274

    Drugs

    Total: 1072
    In Groups: 821

    Interactions

    Total: 5078

    Full Citation

    From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource. McDonagh EM, Whirl-Carrillo M, Garten Y, Altman RB, Klein TE. Biomark Med. 2011 Dec;5(6):795-806. PMID: 22103613

    • Full Name: Targeted Agents in Lung Cancer (Commentary, 2014) Version: 12-May-2016

    Genes

    Total: 191
    In Groups: 159

    Drugs

    Total: 274
    In Groups: 199

    Interactions

    Total: 624

    Full Citation

    A tabulated summary of targeted and biologic therapies for non-small-cell lung cancer. Simon GR, Somaiah N. Clin Lung Cancer. 2014 Jan;15(1):21-51. doi: 10.1016/j.cllc.2013.11.009. Epub 2013 Nov 21. PMID: 24377743

    • Full Name: The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication (Rask-Andersen, Masuram, Schioth 2014) Version: January-2014

    Genes

    Total: 1016
    In Groups: 1013

    Drugs

    Total: 2419
    In Groups: 1735

    Interactions

    Total: 5063

    Full Citation

    The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication. Rask-Andersen M, Masuram S, Schioth HB. Annu Rev Pharmacol Toxicol. 2014;54:9-26. doi: 10.1146/annurev-pharmtox-011613-135943. PMID: 24016212

    • Full Name: Trends in the exploitation of novel drug targets (Rask-Andersen, et al., 2011) Version: 01-August-2011

    Genes

    Total: 437
    In Groups: 436

    Drugs

    Total: 989
    In Groups: 910

    Interactions

    Total: 2243

    Full Citation

    Trends in the exploitation of novel drug targets. Rask-Andersen M, Almen MS, Schioth HB. Nat Rev Drug Discov. 2011 Aug 1;10(8):579-90. PMID: 21804595

  • TTD

    • Full Name: Therapeutic Target Database Version: 2020.06.01

    Genes

    Total: 2763
    In Groups: 1943

    Drugs

    Total: 28644
    In Groups: 6171

    Interactions

    Total: 40468

    Full Citation

    Update of TTD: Therapeutic Target Database. Zhu F, Han BC, ..., Zheng CJ, Chen YZ. Nucleic Acids Res. 38(suppl 1):D787-91, 2010. PMID: 19933260