• Full Name: Bader Lab Genes Version: February-2014

    Genes

    Total: 300
    In Groups: 298

    Full Citation

    Too many roads not taken: Aled M. Edwards, Ruth Isserlin, Gary D. Bader, Stephen V. Frye, Timothy M. Willson & Frank H. Yu Nature 470, 163–165 (10 February 2011) doi:10.1038/470163a. PMID: 21307913

    • Full Name: Caris Molecular Intelligence Version: 07-October-2015

    Genes

    Total: 66
    In Groups: 60

    Full Citation

    http://www.carismolecularintelligence.com/

    • Full Name: dGENE - The Druggable Gene List Version: 27-June-2013

    Genes

    Total: 2257
    In Groups: 2242

    Full Citation

    Prioritizing Potentially Druggable Mutations with dGene: An Annotation Tool for Cancer Genome Sequencing Data. Kumar RD, Chang LW, Ellis MJ, Bose R. PLoS One. 2013 Jun 27;8(6):e67980. PMID: 23826350

    • Full Name: Foundation One Genes Version: 20-September-2013

    Genes

    Total: 243
    In Groups: 242

    Full Citation

    High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. Wagle N, Berger MF, ..., Meyerson M, Gabriel SB, Garraway LA. Cancer Discov. 2012 Jan;2(1):82-93. PMID: 22585170

  • GO

    • Full Name: The Gene Ontology Version: 27-September-2017

    Genes

    Total: 7459
    In Groups: 7327

    Full Citation

    Gene ontology: tool for the unification of biology. The unification of biology. The Gene Ontology Consortium. Ashburner M, Ball CA, ..., Rubin GM, Sherlock G. Nat Genet. 2000 May;25(1):25-9. PMID: 10802651

    • Full Name: Guide to Pharmacology Genes Version: 4-March-2015

    Genes

    Total: 1969
    In Groups: 1969

    Full Citation

    Pawson, Adam J., et al. "The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands." Nucleic acids research 42.D1 (2014): D1098-D1106. PMID: 24234439

    • Full Name: The druggable genome and support for target identification and validation in drug development (Hingorani & Casas, 2017) Version: 31-May-2017

    Genes

    Total: 4479
    In Groups: 4475

    Full Citation

    The druggable genome and support for target identification and validation in drug development. Finan C, Gaulton A, Kurger F, Lumbers T, Shah T, Engmann J, Galver L, Kelly R, Karlsson A, Santos R, Overington J, Hingorani A, Casas JP. Sci. Transl. Med. 2017 Mar 29;9(383):eaag1166 PMID: 28356508

    • Full Name: The druggable genome (Hopkins & Groom, 2002) Version: 11-September-2012

    Genes

    Total: 2676
    In Groups: 2671

    Full Citation

    The druggable genome. Hopkins AL, Groom CR. Nat Rev Drug Discov. 2002 Sep;1(9):727-30. PMID: 12209152

    • Full Name: Memorial Sloan Kettering IMPACT Version: May-2015

    Genes

    Total: 350
    In Groups: 350

    Full Citation

    Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology. Cheng, Donavan T., et al. The Journal of Molecular Diagnostics 17.3 (2015): 251-264. PMID: 25801821

    • Full Name: The druggable genome: an update (Russ & Lampel, 2005) Version: 26-July-2011

    Genes

    Total: 3361
    In Groups: 3085

    Full Citation

    The druggable genome: an update. Russ AP, Lampel S. Drug Discov Today. 2005 Dec;10(23-24):1607-10. PMID: 16376820

    • Full Name: The ChEMBL Bioactivity Database Version: chembl_23

    Drugs

    Total: 9501
    In Groups: 9501

    Full Citation

    The ChEMBL bioactivity database: an update. Bento AP, Gaulton A, Hersey A, Bellis LJ, Chambers J, Davies M, Kruger FA, Light Y, Mak L, McGlinchey S, Nowotka M, Papadatos G, Santos R, Overington JP. Nucleic Acids Res. 42(Database issue):D1083-90. PubMed ID: 24214965

    • Full Name: PubChem Version: 09-Feb-2016

    Drugs

    Total: 12841
    In Groups: 9952

    Full Citation

    PubChem's BioAssay Database. Wang Y, Xiao J, ..., Gindulyte A, Bryant SH. Nucleic Acids Res. 2012 Jan;40(Database issue):D400-12. Epub 2011 Dec 2. PMID: 22140110

    • Full Name: Ensembl Version: 90_38

    Genes

    Total: 58302
    In Groups: 37326

    Full Citation

    Ensembl 2011. Flicek P, Amode MR, ..., Vogel J, Searle SM. Nucleic Acids Res. 2011 Jan;39(Database issue)800-6. Epub 2010 Nov 2. PMID: 21045057

    • Full Name: NCBI Entrez Gene Version: 27-September-2017

    Genes

    Total: 41102
    In Groups: 41102

    Full Citation

    Entrez Gene: gene-centered information at NCBI. Maglott D, Ostell J, Pruitt KD, Tatusova T. Nucleic Acids Res. 2011 Jan;39(Database issue)52-7. Epub 2010 Nov 28. PMID: 21115458

    • Full Name: Cancer Commons Version: 25-July-2013

    Genes

    Total: 48
    In Groups: 48

    Drugs

    Total: 80
    In Groups: 75

    Interactions

    Total: 109

    Full Citation

    Cancer Commons: Biomedicine in the Internet Age. Shrager J, Tenenbaum JM, and Travers M. Collaborative Computational Technologies for Biomedical Research, (Sean Elkins, Maggie Hupcey, and Antony Williams Eds). Wiley, 2010.

  • CGI

    • Full Name: Cancer Genome Interpreter Version: 27-September-2017

    Genes

    Total: 118
    In Groups: 117

    Drugs

    Total: 155
    In Groups: 126

    Interactions

    Total: 372

    Full Citation

    https://www.cancergenomeinterpreter.org/

    • Full Name: The ChEMBL Bioactivity Database Version: chembl_23

    Genes

    Total: 1085
    In Groups: 1084

    Drugs

    Total: 2716
    In Groups: 2715

    Interactions

    Total: 7610

    Full Citation

    The ChEMBL bioactivity database: an update. Bento AP, Gaulton A, Hersey A, Bellis LJ, Chambers J, Davies M, Kruger FA, Light Y, Mak L, McGlinchey S, Nowotka M, Papadatos G, Santos R, Overington JP. Nucleic Acids Res. 42(Database issue):D1083-90. PubMed ID: 24214965

    • Full Name: CIViC: Clinical Interpretations of Variants in Cancer Version: 27-September-2017

    Genes

    Total: 192
    In Groups: 192

    Drugs

    Total: 280
    In Groups: 206

    Interactions

    Total: 650

    Full Citation

    CIViC: Clinical Interpretations of Variants in Cancer

  • CKB

    • Full Name: The Jackson Laboratory Clinical Knowledgebase Version: 27-September-2017

    Genes

    Total: 86
    In Groups: 86

    Drugs

    Total: 733
    In Groups: 418

    Interactions

    Total: 1962

    Full Citation

    Sara E. Patterson, Rangjiao Liu, Cara M. Statz, Daniel Durkin, Anuradha Lakshminarayana, and Susan M. Mockus. The Clinical Trial Landscape in Oncology and Connectivity of Somatic Mutational Profiles to Targeted Therapies. Human Genomics, 2016 Jan 16;10(1):4. (PMID: 26772741)

    • Full Name: Clearity Foundation Biomarkers Version: 26-July-2013

    Genes

    Total: 34
    In Groups: 34

    Drugs

    Total: 64
    In Groups: 57

    Interactions

    Total: 163

    Full Citation

    http://www.clearityfoundation.org/healthcare-pros/drugs-and-biomarkers.aspx

    • Full Name: Clearity Foundation Clinical Trial Version: 15-June-2013

    Genes

    Total: 108
    In Groups: 100

    Drugs

    Total: 115
    In Groups: 85

    Interactions

    Total: 281

    Full Citation

    https://www.clearityfoundation.org/form/findtrials.aspx

    • Full Name: Database of Curated Mutations Version: 27-September-2017

    Genes

    Total: 35
    In Groups: 35

    Drugs

    Total: 39
    In Groups: 37

    Interactions

    Total: 76

    Full Citation

    DoCM: a database of curated mutations in cancer. Ainscough BJ, Griffith M, Coffman AC, Wagner AH, Kunisaki J, Choudhary MN, McMichael JF, Fulton RS, Wilson RK, Griffith OL, Mardis ER. Nat Methods. 2016;13(10):806-7. PMID: 27684579

    • Full Name: DrugBank - Open Data Drug & Drug Target Database Version: 5.0.8

    Genes

    Total: 2354
    In Groups: 2274

    Drugs

    Total: 5005
    In Groups: 3256

    Interactions

    Total: 11293

    Full Citation

    DrugBank 4.0: shedding new light on drug metabolism. Law V, Knox C, Djoumbou Y, Jewison T, Guo AC, Liu Y, Maciejewski A, Arndt D, Wilson M, Neveu V, Tang A, Gabriel G, Ly C, Adamjee S, Dame ZT, Han B, Zhou Y, Wishart DS.Nucleic Acids Res. 2014 Jan 1;42(1):D1091-7. PubMed ID: 24203711

  • FDA

    • Full Name: FDA Pharmacogenomic Biomarkers Version: 15-September-2017

    Genes

    Total: 62
    In Groups: 59

    Drugs

    Total: 204
    In Groups: 192

    Interactions

    Total: 270

    Full Citation

    https://www.fda.gov/drugs/scienceresearch/researchareas/pharmacogenetics/ucm083378.htm

    • Full Name: Guide to Pharmacology Interactions Version: 27-September-2017

    Genes

    Total: 1608
    In Groups: 1496

    Drugs

    Total: 6495
    In Groups: 3938

    Interactions

    Total: 12593

    Full Citation

    Pawson, Adam J., et al. "The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands." Nucleic acids research 42.D1 (2014): D1098-D1106. PMID: 24234439

    • Full Name: My Cancer Genome Version: 20-Jun-2017

    Genes

    Total: 182
    In Groups: 181

    Drugs

    Total: 252
    In Groups: 234

    Interactions

    Total: 865

    Full Citation

    Abramson, R., Aston, J., C. Lovly. 2017. My Cancer Genome.

    • Full Name: MyCancerGenome Clinical Trial Version: 30-February-2014

    Genes

    Total: 83
    In Groups: 80

    Drugs

    Total: 112
    In Groups: 105

    Interactions

    Total: 377

    Full Citation

    http://www.mycancergenome.org/

  • NCI

    • Full Name: NCI Cancer Gene Index Version: 14-September-2017

    Genes

    Total: 1045
    In Groups: 1037

    Drugs

    Total: 1519
    In Groups: 1003

    Interactions

    Total: 6231

    Full Citation

    https://wiki.nci.nih.gov/display/cageneindex

    • Full Name: OncoKB: A Precision Oncology Knowledge Base Version: 27-September-2017

    Genes

    Total: 50
    In Groups: 49

    Drugs

    Total: 99
    In Groups: 76

    Interactions

    Total: 189

    Full Citation

    OncoKB: A Precision Oncology Knowledge Base. Chakravarty D, Gao J, Phillips S, et. al. JCO Precision Oncology 2017 :1, 1-16

    • Full Name: PharmGKB - The Pharmacogenomics Knowledgebase Version: 12-July-2012

    Genes

    Total: 600
    In Groups: 599

    Drugs

    Total: 589
    In Groups: 405

    Interactions

    Total: 1952

    Full Citation

    From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource. McDonagh EM, Whirl-Carrillo M, Garten Y, Altman RB, Klein TE. Biomark Med. 2011 Dec;5(6):795-806. PMID: 22103613

    • Full Name: Targeted Agents in Lung Cancer (Commentary, 2014) Version: 12-May-2016

    Genes

    Total: 191
    In Groups: 158

    Drugs

    Total: 274
    In Groups: 227

    Interactions

    Total: 624

    Full Citation

    A tabulated summary of targeted and biologic therapies for non-small-cell lung cancer. Simon GR, Somaiah N. Clin Lung Cancer. 2014 Jan;15(1):21-51. doi: 10.1016/j.cllc.2013.11.009. Epub 2013 Nov 21. PMID: 24377743

    • Full Name: The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication (Rask-Andersen, Masuram, Schioth 2014) Version: January-2014

    Genes

    Total: 1016
    In Groups: 1013

    Drugs

    Total: 2419
    In Groups: 1872

    Interactions

    Total: 5063

    Full Citation

    The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication. Rask-Andersen M, Masuram S, Schioth HB. Annu Rev Pharmacol Toxicol. 2014;54:9-26. doi: 10.1146/annurev-pharmtox-011613-135943. PMID: 24016212

    • Full Name: Trends in the exploitation of novel drug targets (Rask-Andersen, et al., 2011) Version: 01-August-2011

    Genes

    Total: 437
    In Groups: 436

    Drugs

    Total: 989
    In Groups: 972

    Interactions

    Total: 2243

    Full Citation

    Trends in the exploitation of novel drug targets. Rask-Andersen M, Almen MS, Schioth HB. Nat Rev Drug Discov. 2011 Aug 1;10(8):579-90. PMID: 21804595

  • TTD

    • Full Name: Therapeutic Target Database Version: 4.3.02 (25-August-2011)

    Genes

    Total: 691
    In Groups: 575

    Drugs

    Total: 2720
    In Groups: 2099

    Interactions

    Total: 3049

    Full Citation

    Update of TTD: Therapeutic Target Database. Zhu F, Han BC, ..., Zheng CJ, Chen YZ. Nucleic Acids Res. 38(suppl 1):D787-91, 2010. PMID: 19933260